De Quervain’s disease is a painful inflammatory condition of thumb. (Inflammation (tenosynovitis) of the tendon sheaths of abductor pollicis longus and extensor pollicis brevis of thumb) at the point where they cross the styloid process of radius. The cause is not clear but overuse, any direct injury to thumb, repetitive stress (grasping) and certain inflammatory conditions like rheumatoid arthritis. Pain in the outer border (lateral aspect) of the thump initially later it will spreads to the forearm. Movements of thump are very painful. It may be associated with weakness of handgrip.